Plexigen's primary offering is our services utilizing our geneCube platform technology.
For customers who are interested in having their own complete system, the following four parts that make up the platform can be purchased.
geneCube™ |
Plexstation™ |
geneReader™ |
BioREVELATION™
geneCube™
The geneCube is Plexigen's platform for high-throughput biological testing.
It is a three dimensional microarray capable of performing hundreds of genetic and proteomic tests on hundreds of samples at the same time.
For a detailed description on how the geneCube works see our technology section.
The geneCube is a versatile platform and suitable for many DNA/RNA (such as DNA/RNA hybridization-based assays) and proteomic-based assays
(such as immunology-based assays). We have validated in our laboratory a number of immunoassays for animal disease detection, i.e.,
for porcine reproductive and respiratory syndrome virus (PRRS) (both antibody and antigen detection), swine influenza (both antibody detection),
and foot and mouth disease (FMD) (antibody detection). We are testing assays for detecting antibodies and antigens for Avian influenza,
bovine viral diarrhea virus (BVD), Listeria, Enterococcus, and Salmonella. The system is capable of detection of both antibody and
pathogen for any disease if a monoclonal antibody and purified antigen are available. Users can use commercially available reagents
to implement their assays on the geneCube platform.
Plexstation™
Plexigen's proprietary, non-robotic sample and target delivery system. One Plexstation can
put probes onto a large number of microarrays simultaneously in a matter of a few
minutes. The level of geneCube™ production using a Plexstation is significantly larger than the
production levels of microarrays currently on the market using photolithography or glass-based DNA
microarrays using robotic arrayers. Production using those platforms is on the order of several hundred
microarrays daily. In one operation, a Plexstation can deliver samples to hundreds microarrays.
One Plexstation can potentially deliver samples to more than 2,000 microarrays daily.
This unique process enables rigorous quality control for microarray production, an essential process for any
commercial microarray product. Currently there are two models: one that delivers samples from 384-well microtitter plates
and a larger one that delivers samples from four 96-well mircotitter plates.
geneReader™
The geneReader is our complete system for scanning geneCards.
The current geneReader is capable of scanning an array of 24 cards, about 10,000 data points, in less then 30 minutes.
Data acquisition is done by means of a precision laser and a photomultiplier tube
which counts the arrival of individual photons allowing for exceptionally high resolution and range.
After scanning, the geneReader can send the data directly into a database through Plexigen’s information
handling system or output the data to an EXCEL speadsheet.
The data are provided through a RS232 serial port to a local computer or Ethernet connection
to a remote computer and a LCD touch screen with a simple menu system provides the user interface.
BioRevelation™
A suite of software including: proprietary bioinformatics software package, customizable databases for specific applications,
and analytical/communication tools for WEB-based diagnostics or functional genomics. This suite will
interact with the Plexstation, geneCube and geneReader to provide a turn-key solution for our customers in a broad range
of genomic and proteomic applications. For example, BioRevelation can be used as a diagnostic platform for disease
applications, using geneCube and Internet communications.
Some of BioRevelation's main features include:
- Seamless support for Plexigen's smart-microarray platform
- Knowledge based interactive microarray design
- A suite of bioinformatics applications including data mining
- Integration of data analysis with public and private databases including application specific databases such as:
Drug compounds, Cancers, Clinical trials, Diagnostics, Hospital, Pharmacogenomics.